What Technical Support Comes With the LNP Screening Array?

By Joshua Gomes

Every LNP Screening Array evaluation comes with hands-on technical support from our applications team. We configure the automation protocol for your liquid handler, install it on your deck, and run the first formulations alongside your operators.

Start with a protocol prepared for your liquid handler

Your team starts the evaluation with a method configured for your liquid handler. Our platform-specific protocols account for how air-displacement, positive-displacement, and pressure-controlled pipetting each generate and control flow, so the method is matched to your liquid handler before the first formulation.

We build your evaluation plan around three setup parameters.

Setup considerations	How it shapes your evaluation
Liquid handler make and model	Matches dispensing, positioning, and timing to your pipetting technology
Target formulations + volumes	Sets the volume the protocol dispenses and recovers for each formulation
Analytical readouts	Determines which results we characterize on site and review with your team

The workflow is validated on Hamilton, Tecan, Formulatrix, Opentrons, and Dynamic Devices liquid handlers. If your lab runs another pipette-based system, contact us for a compatibility review.

Get the protocol installed on your deck

Our applications team works alongside your operators on your own formulations, so the first data from your evaluation reflects the conditions relevant to your program screens. During the first run, your team operates the liquid handler while we guide each step.

Installation step	What we do
Deck setup	Position the deck adapter, LNP Screening Arrays, and input and output plates
Protocol installation	Load the automation protocol onto your liquid handler and confirm your operators can launch it from their existing software
Tip check	Confirm your tips form a pressure-tight seal with each pipette interface and engage the LNP Screening Array as intended

Operator training starts during installation on the instrument your team uses every day, and we provide an application guide as a step-by-step reference.

Run your first formulations with our applications team

First-run step	Your operators	Our applications scientists
Input preparation	Prepare lipid and aqueous inputs in the source plate	Confirm the plate layout matches the protocol
Method execution	Run the method through loading, formulation, and collection	Train operators at each step
Troubleshooting	Flags anything unexpected	Diagnose fluid movement or sample recovery issues and adjust the method on site

Get characterization data from your first run

Once the formulations are collected, they are transferred to a DLS instrument for on-site characterization. Our application scientists help you characterize your first-run formulations using dynamic light scattering (DLS), so particle size and polydispersity index (PDI) data are available during the visit. Encapsulation efficiency, in vitro expression, and other biological or characterization readouts can be run as a follow up to match the assays your lab already uses.

The table below shows how each readout is generated and when you review it.

Readout	How it is generated	When you review
Particle size and PDI	On-site DLS by our application scientists	During the visit
Consistency across formulations	On-site DLS across repeated formulations	During the visit
Encapsulation efficiency	Your established assay	During data review
In vitro and biological results	Your established assays, included based on your program	During data review
Side-by-side comparison	Your current formulation method run alongside the LNP Screening Array	During data review

Your team sets the success criteria against your current benchmarks, and our application scientists review every result against them with you. For guidance on defining those criteria, see How to Evaluate an LNP Screening Platform.

Keep the automation protocol for recurring screening

The finished automation protocol stays with your team, so the method refined during the evaluation becomes the method for your recurring screening campaigns. After the visit, our applications scientists continue to support your operators as your screening needs evolve.

Ongoing support	What we provide
On-site and remote support	Help diagnose run, fluid movement, or sample recovery issues as your team begins operating the workflow independently
Method updates	Adapt the protocol when new formulation conditions or process steps enter your screen

What your team has after the evaluation

The goal of the evaluation is to leave your team with a working method, trained operators, and first-run data from the workflow you intend to use.

Evaluation outcome	What your team has in place
Automation method	A platform-specific protocol configured and refined on your liquid handler
Operator workflow	Operators trained to set up, launch, and run the method, with an application guide for reference
First-run data	Particle size and PDI results from formulations generated during the evaluation, reviewed against your success criteria
Ongoing support	Direct access to our applications team for troubleshooting and method updates as your screening workflow evolves

The LNP Screening Array keeps reagent delivery, microfluidic formulation, and sample collection on your liquid handler. Analytical characterization then takes place on the instruments your lab already uses.

For a step-by-step look at the device, see How the LNP Screening Array Works.

Plan your evaluation

Our application scientists bring the LNP Screening Array to your lab and support your team through its first formulations on your own liquid handler.

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