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LNP Screening Array

High-Throughput LNP Screening on the Formulatrix® FLO i8® PD

Ready to start screening more LNP formulations?

Share your contact information and our team will reach out to discuss your liquid handler, screening goals, and next steps.

= required
Parallel LNP Screening Array. A microplate-sized microfluidic device with eight sets of flow focusing micromixers at a 3:1 flow rate ratio.

Turn the FLO i8 PD into an LNP screening platform.

Run automated microfluidic LNP screening on the FLO i8 PD with the LNP Screening Array.

100+ formulations per hour

Increase throughput by removing the formulation bottleneck.

10x faster than LNP instruments

Run formulations in parallel and generate LNPs in seconds.

<50 µL dead volume

Extend valuable lipid and RNA inputs across more formulations.

1 automated workflow

Keep prep workflows, LNP formulation, sample collection, and post-processing in one run.

FLO i8 PD for automated LNP screening

Positive displacement pipetting gives formulation teams direct control over screening conditions that are typically fixed inside dedicated formulation systems.

Positive displacement control
Set flow directly at each channel to control formulation conditions with greater precision.

Higher flow rate capability
Run at flow rates that drive particle size lower during formulation.

Microfluidic formulation on deck
Generate LNPs within your automation workflow instead of handing formulation off to a dedicated instrument.

Performance on the FLO i8 PD

Blank LNP runs on the FLO i8 PD delivered particle size, PDI, and reproducibility aligned with screening-stage formulation targets.

≤100 nm
Mean particle size

≤0.2 PDI
Particle uniformity

3.38% CV
Size reproducibility

The graph above shows workflow performance under blank LNP conditions and particle size decreasing under higher total flow rates.

From reagent setup to LNPs in one automated sequence.

When formulation sits outside the automation workflow, throughput stalls and handoffs multiply. The LNP Screening Array closes that gap on the FLO i8 PD.

1

Prepare reagents on deck.
Set up lipid and aqueous inputs within the liquid handling workflow already running in your lab.

2

Generate LNPs with the array.
Dispense through the LNP Screening Array to run parallel microfluidic formulation on the FLO i8 PD.

3

Move directly into characterization.
Collect samples for sizing and screening without transferring formulation work to an additional system.

Everything you need for a successful run on the FLO i8 PD

Starter Kit

A complete kit built to generate reproducible LNP data on your liquid handler.

LNP Screening Array

  • 8 staggered herringbone micromixers

FLO i8 PD automation protocol

  • Ready-to-run method for automated dispense and formulation

Hold-down adapter

  • Keeps the device seated securely during the run

Compatible 96-well plates

  • For reagent loading and LNP collection

Application guide

  • Setup and run instructions for the FLO i8 PD workflow

Included accessories

  • Auxiliary items required for first-run success

Ready to start screening more LNP formulations?

Share your contact information and our team will reach out to discuss your liquid handler, screening goals, and next steps.

= required

Start screening on the FLO i8 PD.

Parallel Fluidics LNP Screening Array. A microplate-sized microfluidic device with eight sets of flow-focusing micromixers, all with a 3:1 flow rate ratio.

Bring LNP formulation back into the automated workflow your team already runs.

Ready to start screening more LNP formulations?

Share your contact information and our team will reach out to discuss your liquid handler, screening goals, and next steps.

= required

Questions about compatibility or setup? Talk to our applications team.

Technical resources

Fact sheet
High-Throughput LNP Screening on the FLO i8 PD

Whitepaper
Automated Microfluidic LNP Screening on the FLO i8 PD

Press release
Parallel Fluidics and Formulatrix Bring Automated LNP Screening to the FLO i8 PD

FAQ

Positive displacement pipetting allows direct control over formulation conditions at each channel (flow rate ratio, total flow rate), giving teams a more practical way to tune screening runs on deck.

Testing under blank LNP conditions showed mean particle size of 98.7 nm and PDI of 0.20 at 2.5 mL/min, with particle size decreasing across increasing total flow rates.

Dedicated systems can produce quality LNPs, but they also create a break in the automation workflow. This workflow brings formulation back onto the liquid handler so teams can screen more conditions without adding another system to manage.

This workflow is designed for screening-stage formulation work, where throughput, iteration speed, and efficient use of materials matter most.

Request the Starter Kit or contact our applications team to discuss workflow fit and setup: [email protected].

The Starter Kit is packaged to support successful first-run setup on the FLO i8 PD, including the workflow components and guidance required to run on deck.
  • 8 staggered herringbone micromixers for LNP formation
  • 8 1mL anti-backflow reservoirs that prevent reagent backflow during aspiration and dispense cycles
  • 16 pipette interfaces that connect standard pipette tips to the array
  • SLAS microplate footprint that fits standard liquid handler decks

Yes. Demo and evaluation support are available through Parallel Fluidics and Formulatrix.

Most LNP tools require a dedicated instrument, proprietary cartridges, or a separate off-deck workflow. The LNP Screening Array runs directly on your liquid handler, enabling parallel screening and up to 10x faster throughput without a dedicated instrument.

The LNP Screening Array helps teams screen faster, reduce hands-on work, and expand discovery capacity on the liquid handler they already use.