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LNP Screening on Lynx VVP

High-throughput LNP formulation screening on Dynamic Devices Lynx VVP

Get Started

Submit the form and our team will follow up within 24 hours to help you get your Starter Kit.

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Generate LNPs directly on deck.

The LNP Screening Array brings microfluidic formulation into the Lynx VVP workflow. Generate LNPs faster with less manual handling and material loss.

100+ formulations per hour

Expand LNP screening throughput across more conditions.

10x faster than LNP instruments

Generate formulated LNPs in seconds.

<25 µL dead volume

Preserve valuable lipid, RNA, and other limited inputs.

1 automated workflow

Run setup, formulation, and collection on Lynx VVP.

Built for LNP screening on Lynx VVP

Lynx VVP gives formulation teams a pressure-driven automation environment for LNP screening. The workflow connects liquid handling, microfluidic formulation, and sample recovery on deck.

Pressure as a screening variable
Evaluate pressure alongside formulation conditions.

Built for formulation teams
Run LNP screening within your existing liquid handling environment.

On-deck particle generation
Generate and collect LNPs within the Lynx VVP workflow.

Reproducible Particle Quality on Lynx VVP

Testing on Lynx VVP generated blank LNPs with particle size, PDI, and repeatability suitable for formulation development.

Increasing pressure from 225 mbar to 1000 mbar reduced Z-average diameter from 81.9 nm to 49.6 nm while maintaining low PDI across the tested pressure range.

A clearer path from setup to LNPs

Move from reagent setup to microfluidic formulation within the Lynx VVP workflow.

1

Set up inputs.
Prepare lipid and aqueous inputs for the screening run.

2

Generate LNPs on deck.
Dispense into the LNP Screening Array to form particles.

3

Collect samples.
Recover formulated LNPs for sizing and analysis.

Everything needed for a successful first run

Starter Kit

Get the components and guidance needed to evaluate microfluidic LNP formulation on Lynx VVP.

LNP Screening Array

  • Runs high-throughput LNP screening

Lynx VVP automation protocol

  • Ready to run on the Lynx liquid handler

Setup components

  • For sample handling and collection

Get Started

Submit the form and our team will follow up within 24 hours to help you get your Starter Kit.

= required

Start screening LNPs on Lynx VVP

Explore the LNP Screening Array workflow and discuss fit with our team.

Get Started

Submit the form and our team will follow up within 24 hours to help you get your Starter Kit.

= required

Technical resources

Fact sheet
High-Throughput LNP Screening on Lynx VVP

Whitepaper
Automated LNP Formulation Screening on Lynx VVP

FAQ

The LNP Screening Array is a microplate-format microfluidic consumable that enables LNP formulation directly on a standard liquid handler.

It brings reagent input, microfluidic mixing, and sample collection into one automated workflow, allowing teams to screen LNP formulations in parallel using automation they already have in the lab.

The LNP Screening Array gives Lynx users a microfluidic formulation path for high-throughput LNP development, with low dead volume, pressure-driven process evaluation, and on-deck sample recovery.

It is designed to help teams expand screening throughput using automation they already have in the lab.

At 225 mbar, Lynx VVP generated blank LNPs at <81 nm with low variability and a PDI of <0.16, supporting its use for screening-stage LNP formulation work.

Increasing pressure from 225 mbar to 1000 mbar reduced Z-average diameter from 81.9 nm to 49.6 nm while maintaining low PDI across the tested pressure range.

The LNP Screening Array helps teams screen faster, reduce hands-on work, and expand discovery capacity on their Lynx liquid handler.
  • 8 micromixers for LNP formation
  • 8 anti-backflow reservoirs that prevent reagent backflow during aspiration and dispense cycles
  • 16 pipette interfaces that connect standard pipette tips to the array
  • SLAS microplate footprint that fits standard liquid handler decks

No. The LNP Screening Array is designed to make microfluidic LNP formulation accessible through standard liquid handling workflows.

We support protocol setup, workflow configuration, and first-run execution, so your team does not need to develop the microfluidic workflow from scratch.

An evaluation includes LNP Screening Arrays for an initial run, automation protocol configured for your workflow, guided setup on your Lynx VVP, and application support through first results.

The evaluation is designed to help your team confirm compatibility, establish the workflow in your lab, and generate initial LNP screening data using your existing automation environment.

Yes. Demo and evaluation support are available through Parallel Fluidics and Dynamic Devices.

You can book a demo here.